The Priscilla Bacon Hospice Charity welcomed its first customers to the Nelson Place store on Monday.
A range of thrifted and pre-loved items are available to browse, from clothing and homeware to children’s toys, books and bric-a-brac.
The charity fundraises to support Priscilla Bacon Lodge – a hospice near the Norfolk and Norwich University Hospital.
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It previously sat in Unthank Road in Norwich for 40 years.
Money donated to the charity is used to support the hospice’s patients and loved ones by providing top care, bereavement support and transport.
A spokeswoman for the charity said: “We’re so excited to have opened our new store in Dereham.
“Dereham has a great community feel and energy.
“We have already started recruiting volunteers to support the shop and are looking forward to being part of the local community.”