Nagelsmann named the same Germany side for the third match running and it appeared to take its toll as his players lacked energy and creativity.
It was often too easy for Switzerland to implement their gameplan as they stayed compact and organised while Germany probed but struggled to break them down.
Ndoye’s clinical finish – against the run of play – gave Switzerland a huge confidence boost and they started to threaten more on the break, while Germany grew frustrated.
It was the Swiss fans making the noise at half-time as the players went down the tunnel with blotches of red still visible on the pitch, left by objects thrown in celebration.
Germany’s response took a while to arrive as they were wasteful and impatient, resulting in countless shots from outside the box flying over the bar.
Kai Havertz headed over the bar twice and Ilkay Gundogan sliced a shot wide before Fullkrug finally broke the Swiss resistance.
“It’s always important to have players on the bench who can change games,” said Germany manager Nagelsmann.
“We have players who can come in off the bench who are different. We need every player. They can be important for us in every situation.
“[Fullkrug] gives a good argument for both jobs – coming from the starting XI and off the bench. It’s good luck and bad luck for him that he is so good in that role.”
While this performance might humble Germany, they remain one of the favourites to lift the trophy in Berlin and showed character to find the goal they needed to help their route to the final become easier.
For Switzerland, it was another step in the right direction as they continue to make strides under Yakin and they have now progressed from the group stage in their past three Euros appearances.
“I am very proud of the performance but it’s rather sad for the team that we could not take the victory home,” said Yakin.
“But there was a lot of pressure from the Germans so we can say we take the draw. I am happy we didn’t take a defeat.
“It wasn’t enough for first place [in the group] but I think the next opponent also has to watch out for us. We can be very happy.”